@font-face{font-family:"Atkinson Hyperlegible";src:url("../fonts/AtkinsonHyperlegible-Regular.woff2") format("woff2");font-style:normal;font-weight:400;font-display:swap}
@font-face{font-family:"Atkinson Hyperlegible";src:url("../fonts/AtkinsonHyperlegible-Bold.woff2") format("woff2");font-style:normal;font-weight:700;font-display:swap}
:root{
  --text:#18211e;
  --secondary:#4d5753;
  --muted:#707975;
  --rule:#c9cecb;
  --rule-dark:#9ba39f;
  --blue:#264f73;
  --tau:#8d603c;
  --site:#b64735;
  --tubulin-a:#d8e3e7;
  --tubulin-b:#b8ccd3;
  --plate:#f5f7f5;
  --page:#fff;
  --sans:"Atkinson Hyperlegible","Helvetica Neue",Helvetica,Arial,sans-serif;
}
*{box-sizing:border-box}
html{background:var(--page)}
body{margin:0;color:var(--text);background:var(--page);font:16px/1.55 var(--sans);font-synthesis:none;-webkit-font-smoothing:antialiased;text-rendering:optimizeLegibility}
a{color:inherit}
.skip{position:fixed;z-index:10;top:-100px;left:24px;padding:10px 14px;color:#fff;background:var(--text);font-weight:700;text-decoration:none}
.skip:focus{top:20px;outline:3px solid var(--blue);outline-offset:3px}
.page{min-height:100svh}
.header{border-bottom:1px solid var(--rule)}
.header-inner{display:flex;align-items:center;justify-content:space-between;gap:24px;width:min(1180px,calc(100% - 48px));min-height:68px;margin:0 auto}
.name{font-size:1rem;font-weight:700;text-decoration:none}
.site-nav{display:flex;align-items:center;gap:24px}.site-nav a{color:var(--secondary);font-size:.72rem;font-weight:700;text-decoration:none}.site-nav a:hover{text-decoration:underline;text-underline-offset:4px}.site-nav a:focus-visible{outline:3px solid var(--blue);outline-offset:4px}
.main{display:grid;align-content:center;gap:30px;width:min(1180px,calc(100% - 48px));margin:0 auto;padding:34px 0 30px}
.hero{display:grid;grid-template-columns:minmax(0,730px) minmax(300px,1fr);gap:clamp(54px,6vw,94px);align-items:center}
h1{margin:0;font-size:clamp(2.55rem,3.55vw,3.4rem);font-weight:600;line-height:1.09;letter-spacing:-.033em;text-wrap:balance}
.introduction{max-width:720px;margin:25px 0 0;color:var(--secondary);font-size:clamp(1rem,1.15vw,1.12rem);line-height:1.58}
.tau-figure{align-self:stretch;margin:0;border:1px solid var(--rule);background:var(--plate)}
.figure-head{display:flex;align-items:center;justify-content:space-between;gap:16px;min-height:43px;padding:9px 13px;border-bottom:1px solid var(--rule);color:var(--secondary);font-size:.7rem;font-weight:700;letter-spacing:.025em}
.tau-figure svg{display:block;width:100%;height:auto;aspect-ratio:420/292}
.tau-figure figcaption{display:flex;justify-content:space-between;gap:18px;padding:10px 13px 11px;border-top:1px solid var(--rule);color:var(--muted);font-size:.64rem;line-height:1.35}
.tau-figure figcaption span:first-child{max-width:290px}
.microtubule-outline{fill:none;stroke:var(--rule-dark);stroke-width:1.2}
.tubulin-a{fill:var(--tubulin-a);stroke:#98afb7;stroke-width:.65}
.tubulin-b{fill:var(--tubulin-b);stroke:#839da6;stroke-width:.65}
.seam{fill:none;stroke:#8ba1a8;stroke-width:.7;opacity:.85}
.tau-chain{fill:none;stroke:var(--tau);stroke-width:2.15;stroke-linecap:round;stroke-linejoin:round;stroke-dasharray:250;stroke-dashoffset:250;animation:trace 1.25s .18s ease-out forwards}
.tau-contact{fill:var(--tau)}
.phospho-site{fill:var(--site);stroke:var(--plate);stroke-width:1.5;opacity:.4;animation:site-cycle 11s 1.8s ease-in-out infinite}
.altered-tau{transform-box:fill-box;transform-origin:52% 94%;animation:altered-binding 11s 1.8s ease-in-out infinite}
.contact-ring{fill:none;stroke:var(--site);stroke-width:1;opacity:0;transform-box:fill-box;transform-origin:center;animation:contact-cycle 11s 1.8s ease-in-out infinite}
.figure-label{fill:var(--muted);font:600 9px var(--sans);letter-spacing:.02em}
.figure-leader{fill:none;stroke:var(--muted);stroke-width:.7}
.questions{display:grid;grid-template-columns:210px minmax(0,1fr);gap:36px;padding-top:25px;border-top:1px solid var(--rule-dark)}
.questions h2{margin:0;font-size:1.05rem;font-weight:700;line-height:1.35}
.questions h2 span{display:block;margin-bottom:5px;color:var(--muted);font-size:.7rem;font-weight:500}
.question-list{display:grid;grid-template-columns:repeat(2,minmax(0,1fr));gap:8px 40px;margin:0;padding-left:1.2rem}
.question-list li{padding:2px 0 2px 5px;color:var(--secondary);font-size:.93rem;line-height:1.42}
.question-list li::marker{color:var(--blue)}
.footer{border-top:1px solid var(--rule)}
.footer-inner{display:flex;align-items:center;justify-content:space-between;gap:24px;width:min(1180px,calc(100% - 48px));min-height:60px;margin:0 auto}
.footer p{margin:0;color:var(--muted);font-size:.76rem}.footer a{text-underline-offset:3px}
.footer-warning{width:min(1180px,calc(100% - 48px));margin:0 auto!important;padding:0 0 24px;max-width:1180px}
@keyframes trace{to{stroke-dashoffset:0}}
@keyframes altered-binding{
  0%,18%,82%,100%{transform:translate(0,0) rotate(0)}
  37%,62%{transform:translate(10px,-13px) rotate(2.5deg)}
}
@keyframes site-cycle{
  0%,12%,88%,100%{opacity:.35}
  27%,70%{opacity:1}
}
@keyframes contact-cycle{
  0%,19%,78%,100%{opacity:0;transform:scale(.65)}
  26%{opacity:.75;transform:scale(.65)}
  43%,65%{opacity:0;transform:scale(1.5)}
}
@media(max-width:900px){
  .hero{grid-template-columns:minmax(0,1.3fr) minmax(270px,.7fr);gap:38px}
  h1{font-size:clamp(2.35rem,4.8vw,3rem)}
  .questions{grid-template-columns:180px minmax(0,1fr);gap:28px}
  .question-list{gap:8px 28px}
}
@media(max-width:700px){
  .header-inner,.main,.footer-inner{width:min(100% - 40px,1180px)}
  .header-inner{min-height:64px}
  .site-nav{gap:14px}.site-nav a{font-size:.66rem}.site-nav a:first-child{display:none}
  .main{display:block;padding:38px 0 48px}
  .hero{display:block}
  h1{font-size:clamp(2.25rem,10.5vw,3rem);line-height:1.1}
  .introduction{margin-top:22px;font-size:1rem;line-height:1.55}
  .tau-figure{max-width:430px;margin-top:34px}
  .questions{display:block;margin-top:38px;padding-top:23px}
  .questions h2{margin-bottom:18px}
  .question-list{display:block;padding-left:1.15rem}
  .question-list li{padding-top:5px;padding-bottom:5px}
  .footer-inner{min-height:72px}
  .footer p{font-size:.7rem}
}
@media(max-height:760px) and (min-width:701px){
  .header-inner{min-height:60px}
  .main{gap:23px;padding:25px 0 22px}
  h1{font-size:clamp(2.35rem,3.2vw,3.05rem)}
  .introduction{margin-top:18px;font-size:1rem}
  .questions{padding-top:19px}
  .tau-figure svg{max-height:245px}
  .footer-inner{min-height:54px}
}
@media(prefers-reduced-motion:reduce){
  .tau-chain{animation:none;stroke-dashoffset:0}
  .altered-tau,.phospho-site,.contact-ring{animation:none}
}
@media(forced-colors:active){
  .question-list li::marker{color:CanvasText}
  .tubulin-a,.tubulin-b,.tau-contact,.phospho-site{fill:CanvasText}
  .tau-chain,.microtubule-outline,.seam{stroke:CanvasText}
}
@media print{
  .page{min-height:0}
  .main{display:block;padding:28px 0}
  .tau-chain{animation:none;stroke-dashoffset:0}
  .altered-tau,.phospho-site,.contact-ring{animation:none}
  .site-nav,.footer-warning{display:none}
}

.story-section{padding:clamp(72px,8vw,118px) 0;border-top:1px solid var(--rule-dark)}
.story-section--plate{background:var(--plate)}
.story-section--ink{color:#f5f7f5;background:var(--text)}
.section-inner{width:min(1180px,calc(100% - 48px));margin:0 auto}
.section-heading{margin-bottom:clamp(34px,5vw,62px)}
.section-label{margin:0 0 10px;color:var(--blue);font-size:.68rem;font-weight:750;letter-spacing:.075em;text-transform:uppercase}
.section-heading h2{max-width:900px;margin:0;font-size:clamp(2.45rem,5.2vw,5.5rem);font-weight:600;line-height:.95;letter-spacing:-.05em;text-wrap:balance}
.split-heading{display:grid;grid-template-columns:minmax(0,1.35fr) minmax(260px,.65fr);gap:clamp(40px,7vw,100px);align-items:end}
.split-heading>p{max-width:420px;margin:0;color:var(--secondary);font-size:.86rem;line-height:1.6}
.story-section--ink .section-label{color:#91b9da}.story-section--ink .split-heading>p{color:#bdc8c3}
.mission-intro{display:grid;grid-template-columns:minmax(0,1.2fr) minmax(280px,.8fr);gap:clamp(45px,8vw,110px);padding-top:32px;border-top:1px solid var(--rule-dark)}
.prose-lead p{max-width:720px;margin:0 0 18px;color:var(--secondary);font-size:clamp(1.08rem,1.6vw,1.35rem);line-height:1.55}
.mission-intro blockquote{margin:0;padding-left:25px;border-left:3px solid var(--tau);font-size:clamp(1.4rem,2.5vw,2.25rem);font-weight:600;line-height:1.16;letter-spacing:-.035em}
.mission-ledger{display:grid;grid-template-columns:repeat(5,1fr);margin-top:58px;border-top:2px solid var(--text);border-bottom:1px solid var(--rule-dark)}
.mission-ledger>div{min-height:190px;padding:18px 18px 22px;border-right:1px solid var(--rule)}.mission-ledger>div:last-child{border-right:0}
.mission-ledger span,.process span,.journal-preview span,.article-kicker,.meta-label{color:var(--blue);font-size:.64rem;font-weight:750;letter-spacing:.055em;text-transform:uppercase}
.mission-ledger h3{margin:28px 0 8px;font-size:1.18rem}.mission-ledger p{margin:0;color:var(--secondary);font-size:.76rem;line-height:1.5}
.scenario{max-width:930px;margin:0 0 45px;font-size:clamp(1.25rem,2.15vw,2rem);line-height:1.35;letter-spacing:-.025em}
.process{display:grid;grid-template-columns:repeat(7,1fr);margin:0;padding:0;border-top:2px solid var(--text);border-bottom:1px solid var(--rule);list-style:none}
.process li{position:relative;min-height:205px;padding:17px 14px;border-right:1px solid var(--rule)}.process li:last-child{border-right:0}
.process strong{display:block;margin-top:42px;font-size:.9rem}.process p{margin:7px 0 0;color:var(--secondary);font-size:.7rem;line-height:1.45}
.boundary-ledger{display:grid;grid-template-columns:1fr 1fr;margin-top:48px;border:1px solid var(--rule-dark)}
.boundary-ledger>div{padding:24px}.boundary-ledger>div+div{border-left:1px solid var(--rule-dark)}.boundary-ledger p{margin:8px 0 0;color:var(--secondary);font-size:.84rem}
.daily-promise{display:grid;grid-template-columns:minmax(0,1fr) auto;gap:45px;align-items:end;padding:30px 0 38px;border-top:1px solid #65706c}
.daily-promise p{max-width:790px;margin:0;color:#d5ddda;font-size:1.05rem;line-height:1.65}.text-link{font-size:.8rem;font-weight:750;text-underline-offset:5px}
.story-section--ink .text-link{color:#fff}
.journal-preview{border-top:2px solid #f5f7f5}
.journal-preview a{display:grid;grid-template-columns:170px minmax(250px,.75fr) minmax(300px,1.25fr);gap:25px;padding:22px 0;border-bottom:1px solid #59635f;color:inherit;text-decoration:none}
.journal-preview a:hover strong{text-decoration:underline;text-underline-offset:4px}.journal-preview span{color:#91b9da}.journal-preview strong{font-size:1.06rem}.journal-preview p{margin:0;color:#bdc8c3;font-size:.78rem}
.standards-list{border-top:2px solid var(--text)}
.standards-list>div{display:grid;grid-template-columns:180px 1fr;gap:30px;padding:17px 0;border-bottom:1px solid var(--rule)}.standards-list span{font-weight:700}.standards-list p{margin:0;color:var(--secondary);font-size:.84rem}
.status-note{display:grid;grid-template-columns:1fr 1fr;gap:50px;margin-top:48px;padding:24px;border:1px solid var(--rule-dark);background:var(--plate)}.status-note p{margin:0;color:var(--secondary);font-size:.78rem}

.publication-header{border-bottom:1px solid var(--rule)}
.publication-header .header-inner{min-height:58px}.publication-header .back{color:var(--muted);font-size:.7rem;font-weight:700;text-decoration:none}
.journal-main,.article-main{width:min(1180px,calc(100% - 48px));margin:0 auto}
.journal-hero{display:grid;grid-template-columns:minmax(0,1.25fr) minmax(280px,.75fr);gap:70px;padding:clamp(65px,9vw,125px) 0 55px;border-bottom:2px solid var(--text)}
.journal-hero h1,.article-hero h1{margin:10px 0 0;font-size:clamp(3.5rem,8vw,8rem);font-weight:600;line-height:.86;letter-spacing:-.065em;text-wrap:balance}
.journal-hero .deck{align-self:end;margin:0 0 8px;color:var(--secondary);font-size:1.05rem;line-height:1.65}
.issue-rule{display:grid;grid-template-columns:repeat(3,1fr);border-bottom:1px solid var(--rule-dark)}.issue-rule div{padding:22px 18px;border-right:1px solid var(--rule)}.issue-rule div:last-child{border-right:0}.issue-rule strong{display:block;font-size:2rem}.issue-rule span{color:var(--muted);font-size:.7rem}
.journal-intro{display:grid;grid-template-columns:210px 1fr;gap:45px;padding:60px 0 30px}.journal-intro h2{margin:0;font-size:1.1rem}.journal-intro p{max-width:760px;margin:0;color:var(--secondary);font-size:1rem}
.edition-actions{display:grid;grid-template-columns:repeat(3,1fr);margin:10px 0 60px;border-top:1px solid var(--rule-dark);border-bottom:1px solid var(--rule-dark)}.edition-actions>div{padding:18px;border-right:1px solid var(--rule)}.edition-actions>div:nth-child(3){border-right:0}.edition-actions .edition-question{grid-column:1/4;display:grid;grid-template-columns:190px 1fr;gap:25px;border-top:1px solid var(--rule);border-right:0;background:var(--plate)}.edition-actions span{color:var(--blue);font-size:.63rem;font-weight:750;text-transform:uppercase}.edition-actions p{margin:12px 0 0;color:var(--secondary);font-size:.76rem}.edition-actions .edition-question p{margin:0;font-size:.9rem;font-weight:600}
.journal-index{border-top:2px solid var(--text);margin-bottom:100px}.journal-index article{display:grid;grid-template-columns:70px minmax(260px,.75fr) minmax(300px,1.25fr) 120px;border-bottom:1px solid var(--rule)}.journal-index article>*{padding:25px 18px;border-right:1px solid var(--rule)}.journal-index article>*:last-child{border-right:0}.journal-index h2{margin:0;font-size:1.35rem;line-height:1.2}.journal-index h2 a{text-decoration:none}.journal-index h2 a:hover{text-decoration:underline;text-underline-offset:4px}.journal-index p{margin:0;color:var(--secondary);font-size:.8rem}.journal-index time{color:var(--muted);font-size:.68rem}
.article-hero{padding:clamp(60px,9vw,120px) 0 58px;border-bottom:2px solid var(--text)}.article-hero h1{max-width:1040px;font-size:clamp(3.1rem,7vw,7rem)}.article-deck{max-width:790px;margin:28px 0 0;color:var(--secondary);font-size:clamp(1.08rem,1.7vw,1.35rem);line-height:1.55}
.article-shell{display:grid;grid-template-columns:210px minmax(0,720px);gap:clamp(45px,8vw,110px);padding:55px 0 100px}.article-meta{align-self:start;position:sticky;top:24px}.article-meta dl{margin:0;border-top:2px solid var(--text)}.article-meta div{padding:13px 0;border-bottom:1px solid var(--rule)}.article-meta dt{color:var(--muted);font-size:.62rem;font-weight:750;text-transform:uppercase}.article-meta dd{margin:4px 0 0;font-size:.75rem}
.article-body{font-family:Georgia,"Times New Roman",serif;font-size:1.08rem;line-height:1.72}.article-body>p:first-child{font-size:1.3rem;line-height:1.58}.article-body h2{margin:2.3em 0 .65em;font:600 2.05rem/1.05 var(--sans);letter-spacing:-.035em}.article-body h3{margin:1.8em 0 .5em;font:700 1rem/1.3 var(--sans)}.article-body ul,.article-body ol{padding-left:1.35em}.article-body li{margin:.45em 0}.article-body blockquote{margin:2em 0;padding:20px 0 20px 25px;border-left:3px solid var(--tau);font:600 1.65rem/1.25 var(--sans);letter-spacing:-.025em}.article-body .scope-note{margin:2.5em 0;padding:20px;border:1px solid var(--rule);background:var(--plate);font:normal .8rem/1.55 var(--sans)}.article-body .principle-list{margin:2em 0;border-top:2px solid var(--text);font-family:var(--sans);list-style:none;padding:0}.article-body .principle-list li{display:grid;grid-template-columns:130px 1fr;gap:25px;margin:0;padding:15px 0;border-bottom:1px solid var(--rule);font-size:.84rem}.article-body .principle-list strong{color:var(--blue)}.article-sources{margin-top:3em;padding-top:20px;border-top:1px solid var(--rule);font:normal .73rem/1.55 var(--sans);color:var(--muted)}.article-sources a{text-underline-offset:3px}.article-next{display:flex;justify-content:space-between;gap:30px;padding:30px 0;border-top:1px solid var(--rule);font-size:.78rem;font-weight:700}

@media(max-width:900px){.mission-ledger{grid-template-columns:repeat(3,1fr)}.mission-ledger>div:nth-child(3){border-right:0}.mission-ledger>div:nth-child(n+4){border-top:1px solid var(--rule)}.process{grid-template-columns:repeat(4,1fr)}.process li:nth-child(4){border-right:0}.process li:nth-child(n+5){border-top:1px solid var(--rule)}.journal-preview a{grid-template-columns:140px .8fr 1.2fr}.journal-index article{grid-template-columns:55px .8fr 1.2fr}.journal-index time{grid-column:2/4;border-top:1px solid var(--rule)}}
@media(max-width:700px){.story-section{padding:62px 0}.section-inner,.journal-main,.article-main{width:min(100% - 40px,1180px)}.section-heading h2{font-size:2.75rem}.split-heading,.mission-intro,.daily-promise,.journal-hero,.article-shell{grid-template-columns:1fr}.split-heading{gap:22px}.mission-intro{gap:30px}.mission-ledger{grid-template-columns:1fr 1fr;margin-top:40px}.mission-ledger>div:nth-child(n){min-height:170px;border-top:1px solid var(--rule);border-right:1px solid var(--rule)}.mission-ledger>div:nth-child(even){border-right:0}.mission-ledger>div:last-child{grid-column:1/3;border-right:0}.process{grid-template-columns:1fr 1fr}.process li:nth-child(n){min-height:175px;border-top:1px solid var(--rule);border-right:1px solid var(--rule)}.process li:nth-child(even){border-right:0}.boundary-ledger,.status-note{grid-template-columns:1fr}.boundary-ledger>div+div{border-left:0;border-top:1px solid var(--rule-dark)}.journal-preview a{grid-template-columns:1fr;gap:6px}.journal-preview p{margin-top:4px}.standards-list>div{grid-template-columns:110px 1fr}.journal-hero{gap:30px}.journal-hero h1,.article-hero h1{font-size:3.7rem}.issue-rule strong{font-size:1.6rem}.journal-intro{grid-template-columns:1fr;gap:12px}.edition-actions{grid-template-columns:1fr}.edition-actions>div:nth-child(n){border-right:0;border-bottom:1px solid var(--rule)}.edition-actions .edition-question{grid-column:1;grid-template-columns:1fr;gap:6px}.journal-index article{grid-template-columns:42px 1fr}.journal-index article p,.journal-index time{grid-column:2}.journal-index article p,.journal-index time{border-top:1px solid var(--rule)}.article-shell{gap:35px}.article-meta{position:static}.article-meta dl{display:grid;grid-template-columns:1fr 1fr}.article-meta div{padding-right:15px}.article-body{font-size:1.02rem}.article-body>p:first-child{font-size:1.2rem}.article-body .principle-list li{grid-template-columns:1fr;gap:4px}.footer-warning{width:min(100% - 40px,1180px)}}
@media(max-width:460px){.site-nav a:nth-child(1){display:none}.site-nav{gap:11px}.site-nav a{font-size:.61rem}.mission-ledger{grid-template-columns:1fr}.mission-ledger>div:last-child{grid-column:1}.process{grid-template-columns:1fr}.process li:nth-child(n){border-right:0}.standards-list>div{grid-template-columns:1fr;gap:5px}.issue-rule div{padding:16px 10px}.issue-rule strong{font-size:1.35rem}.journal-hero h1,.article-hero h1{font-size:3.15rem}}